Research has characterized MC4R-mediated signaling in the paraventricular nucleus of the hypothalamus as a key site of activity in preclinical reproductive behavior models (Shadiack et al., 2007)
However, the statistical significance of this pathway was likely attributable to androgen metabolites, as we did not see any difference in estrogen metabolites
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8,74 Insulin also increases the enzymatic activity of both hexokinase and 6-phosphofructokinase which results in enhanced glycolysis and glucose metabolism
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