However, in a Y-79 human retinoblastoma xenograft nude mouse model (0.05 g per mouse, intraperitoneal injection, 5 times weekly for 5 weeks), the drug caused 90% mortality, weight loss, lethargy, and mild bilateral renal tubular calcification, suggesting significantly increased systemic and nephrotoxicity risks under specific high-dose or long-term administration conditions (Sabet et al., 1999)
Glutathione is a substance that occurs naturally in the body and it is produced in the liver
Regulatory considerations and safety concerns
147 Additionally, by incorporating advanced hydrogel-based delivery systems, the targeted administration of therapeutic agents such as growth factors and small RNAs can be optimized to minimize off-target effects while maximizing cardiac functional recovery
these events may lead to dehydration, which could cause acute kidney injury if severe
doi: 10.1007/s11947-022-02807-2 238