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ROS is a product of cellular redox metabolism, and moderate amounts of ROS in the epididymis can play a role in sperm maturation and capacitation by regulating cAMP levels (Luan et al., 2019)

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Angiogenesis and hypoxia in the kidney

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HisF is involved in histidine biosynthesis catalyzing the closure of the imidazole ring 33

Additionally, the observation that changes in symptoms as assessed by PainDetect are correlated with changes in the CNFD in the ARA 290 treatment group alone, further support a functional relationship between small fiber density and neuropathic symptoms