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Endothelial apoptosis, membrane abnormalities, and mitochondrial damage are all features of systemic inflammation induced by BBB disruption [67, 71]

When used as second-line therapy, more efficacious agents further improved clinical outcomes but also contributed to higher direct costs over patients lifetimes

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Contrave: Suicidal thoughts and behaviors Contrave contains bupropion, an antidepressant that can increase the risk of suicidal thoughts and actions, especially in children, teenagers, and young adults under age 25 years

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