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The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A

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[1] Important safety considerations include the risk of hypoglycaemia when combined with insulin or sulfonylureas, potential dehydration and acute kidney injury with severe gastrointestinal symptoms, and for semaglutide specifically, possible worsening of diabetic retinopathy in those with pre-existing disease