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So while these medications are very effective and have been studied in long trials, there is a substantial portion who won't achieve at least 5% weight loss

Adverse Events As described in the clinical study report, nonserious adverse events (AEs) not fulfilling any of the prespecified criteria were not systematically collected

Compounded semaglutide lacks this clinical testing

In the retatrutide trials, a dose range of 1 to 12 mg per week subcutaneously was studied

Legal and Ethical Issues : There have been some instances where compounded versions of medications are produced and sold in ways that violates patent laws or other regulations, putting both the compounder and the patient at risk

Endocrinol Metab Clin North Am 2013