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Skip if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

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Each GLP-1RA exposed patient was subsequently matched to one control based on the following factors: age at the time of ICU admission ( 3 yr), sex, body mass index (BMI) ( 0.5 kg/m 2 ), smoking status, presence of obesity (determined via BMI 30 kg/m 2 []), DM (determined by International Classification of Diseases , 10th Edition [ICD-10] codes), motility altering prescription drugs ( eTable 2 , comorbidities associated with decreased motility ( eTable 3 , history of abdominal surgeries (eTable 3, any surgery within 48 hours of ICU admission, Charlson Comorbidity Index (CCI, categorized as groups of 0, 12, 34, and 5) ( , ), and Acute Physiology and Chronic Health Evaluation (APACHE)-III score ( 1 U)

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The glucagon component increases energy expenditure and shifts metabolism toward fat oxidation while sparing muscle tissue

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This decline correlates directly with reduced regenerative capacity and visible signs of aging

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