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Less protein means less raw material for muscle protein synthesis

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The frequency and severity of gastrointestinal effects represent a significant clinical consideration

For instance, past studies show that GLP-1s may also aid in treating cardiovascular disease, chronic kidney disease, non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), and rheumatic diseases, such as rheumatoid arthritis and osteoarthritis

Still, while the new combinations would be great for people who need to lose more weight, Korner said, not everyone needs the so-called big gun. Drugs like retatrutide may be most appropriate for someone who has a body mass index above 45 above 30 is considered obese and for whom existing drugs havent worked sufficiently, Dushay said

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