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Although ferroptosis was first described in cancer cells [10] and its role in cancer biology is well established [11], its relevance has been extended to other diseases such as neurodegeneration, ischemia, and immune disorders [5]

Interestingly, nanoparticle (NP)-induced cell death has been described recently as being consistent with the new 5 R principle

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury through Inhibiting ACSL4 Mediated Ferroptosis

Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia

This exceptional selectivity profile enables researchers to attribute observed effects specifically to NNMT inhibition, rather than off-target activities that plague less specific compounds