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For instance, telomerase inhibitor triethylenetetramine (TETA) in the treatment of breast cancer [122], glycolysis inhibitor 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3-PO) in NSCLC cells [194], respiratory chain complex I inhibitor metformin, ATP synthase inhibitor oligomycin A and Bcl-2 inhibitor venetoclax in CLL patient-derived cells [104]

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The molecule isnt known to produce tolerance or downregulation that would require breaks

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