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In Phase 3 TRIUMPH-4 trials, 33% of participants at the 12 mg dose experienced diarrhea compared to 13.4% on placebo

Depending on the dose, medication type, and injection frequency, some men feel great after an injection and then worse as levels fall

This occurs because parts of the brain that drive eating behaviors overlap extensively with the drive to use alcohol or other substances 24

Retatrutide Phase 2 data showed insulin resistance reductions of over 50% from baseline at higher doses, with fasting insulin levels dropping by up to 71%

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Novo Nordisk's NovoCare program offers a self-pay option that can reduce this to approximately $199$349/month for eligible cash-pay patients