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These principles must not be applied outside a regulated clinical trial or supervised clinical setting

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In AD, along with amyloid and tau phosphorylation, there is an associated increase in inflammation/glial activation, a decrease in synaptic function, an increase in astrocyte activation, and a state of insulin resistance

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These medications, which mimic hormones that regulate appetite, vary in their formulation, dosing schedules, and approved uses

Patients should tell their doctor if each dose increase brings stronger nausea, fatigue, reflux, constipation, or inability to eat