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The compound is currently in Phase 3 clinical trials with expected FDA approval in late 2026 to early 2027

5 mg Vials (TB500, 5 mg each) 8 weeks 8 vials 12 weeks 12 vials 16 weeks 16 vials 10 mg Vials (TB500, 10 mg each) 8 weeks 4 vials 12 weeks 7 vials 16 weeks 10 vials Insulin Syringes (U100) Per week: 7 syringes (1/day) 8 weeks: 56 syringes 12 weeks: 84 syringes 16 weeks: 112 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per vial for reconstitution

JAMA 314, 687699

342 The tri-agonist lowered body weight in diet-induced obese mice by 26.6% after 20 days of treatment, whereas the GLP-1R/GIPR coagonist lowered body weight by 15.7%, and it was found that the action of the tri-agonist occurred in a dose-dependent manner

Researchers in 2026 should evaluate both compounds against current Phase 3 data as it becomes available