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Podocytes are an important structure in the glomerular filtration membrane, and their damage is an obvious pathological change in DN

Also, mutations in the SNCA gene, which plays a role in synaptic function and DA transmission, are associated with the formation of Lewy vesicles, impaired mitochondrial function, age-related neurodegeneration, and death of dopaminergic neurons

Niacin also exerts its own action by binding to receptors expressed on immune cells, notably Gpr109a (also known as HCA2), thereby mediating anti-inflammatory effects [21]

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