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However, research suggests that maintaining adequate B12 levels may help with weight management by improving energy levels[2] and overall metabolic efficiency[1], particularly for those with a deficiency

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[1] Unlike the folic acid derivative leucovorin, folic acid is not clinically useful in offsetting the action of folate reductase inhibitors because it requires the enzyme dihydrofolate reductase for activation

Vitamin B12 is a vital nutrient that plays a key role in the production of red blood cells, maintaining healthy nerve function, and supporting DNA synthesis

Across those trials the compound's tolerability was reported as comparable to placebo, with no statistically significant effects detected on serum IGF-1, fasting glucose, insulin, HbA1c, cortisol, or thyroid hormones at the levels studied, and no serious adverse events attributed to the compound [7]

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