2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee
As with many drugs, you get the desired effect, but you also get undesirable side effects

Hexarelin diminishes within weeks Long-term Use: Ipamorelin preferred for protocols exceeding 2-4 weeks Synergy with GHRH: Both synergize with CJC-1295/Sermorelin Hexarelin Cardiac Research Hexarelin has unique cardiac properties: Cardiac GHS Receptors: Activates GH secretagogue receptors in heart tissue Cardioprotection: Demonstrated protective effects in ischemia/reperfusion models LV Function: Improved left ventricular function in heart failure research Unique Among GHRPs: These cardiac effects are not shared by Ipamorelin Research Application Differences Application-specific preferences: Pure GH Research: Ipamorelin (clean signal, no confounding) Cardiac Research: Hexarelin (unique cardiac effects) Long-term Protocols: Ipamorelin (no desensitization) Acute Maximal GH: Hexarelin (highest peak, short-term only) Safety and Tolerability Profile Hexarelin Safety Profile: Cortisol Elevation: Significant

Long-term prospective studies and well-designed interventions are essential to evaluate effects on thyroid function, immune response, and patient-centered outcomes
They're not approved for anti-aging or body composition uses, and many compounding pharmacies have stopped offering them or require more documentation
It drives physical, mental, and emotional well-being throughout mens lives