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Long-term use doesn't damage metabolism

Further studies using a 23-hour psychophysical sucrose detection task also showed that tesofensine might not affect the perception of sweetness or its palatability responses, even though it is a weight-loss drug

References Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ et al

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( G , H ) Representative Western blots and quantification of p53 (normalized to -actin) in NMCMs treated with or without the JNK inhibitor SP600125 (10 M) for 30 min followed by transfection with control siRNA or Mc5r targeting siRNA for 24 h

Satiety signaling in the hypothalamus, reducing hunger and calorie intake