G6pdh chon mice showed an upregulation of KEGG pathways for proteasome, protein processing in ER and ferroptosis, suggesting that G6PDH deletion affects proteostasis and lipid peroxidation, processes that can be linked to increased oxidative load
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Glutathione (GSH) Key Research Facts Chemical identity: Tripeptide gamma-glutamyl-cysteinyl-glycine (Glu-Cys-Gly) Molecular weight: 307.32 Da (reduced form, GSH) Cellular concentration: 110 mM in cytosol