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Pregnancy and lactation safety has not been systematically studied, and as with most cosmetic and research compounds lacking definitive pregnancy safety data, conservative practice typically suggests avoiding use during pregnancy unless clearly needed, though the natural occurrence of GHK-Cu in the body and minimal systemic absorption from topical use suggest risk is likely to be low

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It's also been suggested that excessive ROS production may contribute to oxidative skeletal muscle fatigue, which will have a damaging effect on both immediate performance and recovery 7

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