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Qishen Yiqi Formula not only inhibits the NF-B pathway to reduce inflammatory responses, but also regulates metabolic reprogramming of PASMCs through the HIF-1 signaling pathway to inhibit glycolysis-related proliferation

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Pro-repair signaling

Therefore, although DPP-4 inhibitors have attractive clinical features, the benefits that might be expected from GLP-1 signaling may be undermined by their actions to enhance SDF-1