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406 This indicates that FGF21 not only plays a role in cellular stress responses but also has a significant role in regulating brain function and systemic metabolism

Front Neurosci 2019;13:38

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Another clinical trial utilized NR to help ameliorate heart failure (HF), which is also characterized by a decline in NAD + levels in whole blood 317,318

Creatine Supplementation Does Not Decrease Total Plasma Homocysteine in Chronic Hemodialysis Patients. Kidney International, vol