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Although liraglutide treatment led to a decrease in pro-inflammatory microbial species (e.g., EscherichiaShigella, Megamonas , and Bacillus ) in DM2 patients, no statistically significant differences were observed when compared to metformin treatment

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These results were well predicted by the plasma stability of the hybrids as all the compounds ( 2 , 5 and 9 ) with similar plasma stability to peptide 1 gave comparable results in vivo