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2022;57(14) doi: 10.1016/j.devcel.2022.06.005

In some cases, they have even been associated with adverse effects, such as the increased risk of prostate cancer linked to vitamin E supplementation (Klein et al., 2011) (for more details, see Table 1)

Typical dosages range from 1000 mcg, varying by administration frequency

EllisJLKarlJPOliverioAMFuXSoaresJWWolfeBEet al

Mechanistically, GAS5 inhibits proliferation and promotes apoptosis through the regulation of E2F1, p21, and p53, and suppresses oncogenic pathways including EGFR, MAPK, and AKT

Second, the EEG endpoint that defined the compounds activity is a population-level pattern in the recipient cortex, not a molecular readout meaning the discovery established a phenomenology, not a pathway