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doi: 10.2337/db22-0015, 21

Strength training becomes increasingly important as weight loss progresses

This triple agonism strategy builds upon the remarkable clinical success of dual GLP-1/GIP agonists like tirzepatide, which have shown unprecedented weight loss efficacy, by adding a third mechanism - glucagon receptor activation - to further enhance metabolic benefits, particularly energy expenditure and hepatic fat oxidation

It's not a localized agent

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