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Its primary licensed indication in the United States, under the brand name Egrifta is the reduction of excess visceral adipose tissue (VAT) in people living with HIV-associated lipodystrophy

Additionally, GLP-1 and its homolog GLP-2 exhibited inhibitory effects on nociceptive pain induced by thermal and chemical stimuli [25]

After 72 weeks of treatment, participants taking tirzepatide lost 20.2% of their body weight (about 50.3 pounds), while those taking semaglutide lost 13.7% (about 33.1 pounds) of their body weight

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Severe gastrointestinal intolerance Some researchers experience debilitating nausea and vomiting that does not improve with standard titration

Hair shedding has been reported during weight loss, but current evidence does not prove that retatrutide directly causes it