retatrutide phase 2 nejm 2023 weight loss percent 48 weeks Trial of for Obesity This week's most cited articles:

It is unclear what would happen to peoples habits after they stop using the drugs, or whether there would be a lasting impact on users health and consumption patterns

Earlier evidence for retatrutide comes from a Phase 2 trial in NEJM in 2023, which reported 24.2% weight loss at 12 mg over 48 weeks

Although much research has focused on mechanisms within the central nervous system to explain this pain suppression 8 , we hypothesize that additional mechanisms occurring in the peripheral nervous system are based on hormonal regulation during digestion

Nevertheless, GLP-1 drugs are skyrocketing in popularity even in those without T2D

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The same pattern is expected with retatrutide, though long-term discontinuation data is not yet available