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Supplementing methyl-folate may be helpful in your case I have a double gene mutation for hereditary hemochromatosis

In addition, mitochondrial swelling also appears to increase with age due to the increased opening of mitochondrial permeability transition pore (mPTP)

others see subtle improvements

Xu X, Lemaire C, Grzych JM, Pierce RJ, Raccurt M, Mullier F, Zerimech F, Decavel JP, Peyrol S, Liu J, Fontaine J, Lafitte S, Capron A and Cesbron JY

By the time it's recognized that you have B12 deficiency, you probably only realize your levels are lower now than they've been for some time now