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Although there was a significant difference between the growth of vadK and vadK:vadK , complementation was incomplete, suggesting that expression of vad K from the chromosomally distant att B site where we re-inserted it into the genome using pMV306 under its native promoter was insufficient

GI-related side effects were the most common, accounting for approximately 49% of all adverse events

Of note, MLH1 and MSH2 carriers have the highest risk of colorectal cancer, generally in the range of 43%-52% by age 70