glp 1 deficiency GLP-1 therapy is becoming a widespread pharmaceutical treatment for obesity and type 2 diabetes, but there are side effects. Many users develop deficiencies in critical nutrients like vitamin D, iron, and B GLP-1 Medications & Your Skin:

It is important not to exceed the recommended doses to avoid potential complications

Evidence from in vitro, animal, and small human studies indicates low toxicity

FOXO4-DRIs intracellular effects persist for 4872 hours once the FOXO4p53 interaction is disrupted, even though the peptides circulating half-life is only 24 hours

Mut Res Fundam Mol Mech Mutagen 690:4049 Garcion E, Sindji L, Leblondel G, Brachet P, Darcy F (1999) 1,25-dihydroxyvitamin D3 regulates the synthesis of -glutamyl transpeptidase and glutathione levels in rat primary astrocytes

Here is a clear comparison to help you understand how each works and when one may be more appropriate

Proteins 71, 1623 (2008)