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Berberine works through multiple mechanisms, including activating AMP-activated protein kinase (AMPK), often referred to as the body's "metabolic master switch." This activation not only enhances GLP-1 secretion but also improves glucose metabolism and lipid profiles

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Another important factor for hepatic lipogenesis Carbohydrate Response-Element Binding Protein (ChREBP) (Postic C and Girard J, 2008) which triggers peripheral insulin resistance and increased glucose production