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Diabetes Care 38 , 476481 (2015)

Retatrutide outperforms both

DPP-IV resistance is achieved through an -aminoisobutyric acid (Aib) substitution at position 2, blocking the proteolytic cleavage that normally inactivates incretin peptides within minutes of secretion

Most people tolerate both medication types well after initial adjustment

When drug levels are temporarily higher due to early dosing, gastric emptying slows further

For those managing type 2 diabetes along with weight loss, oats and quinoa offer an added perk: they improve insulin sensitivity and help stabilize blood sugar levels, unlike refined carbs such as white rice or pasta