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"There are many additional weight loss drugs that are in clinical trials and coming out in the next three to five years," Funai says
Key findings (Vafaei et al., 2025): 30-50 mg/kg mirtazapine: dose-dependent seizure suppression Mediated by CB1/CB2 activation (proven by antagonist blockade) GABA-independent mechanism (distinct from benzodiazepines) Appetite/weight gain provides in-vivo functional validation of CB1 engagement The broader implication: Clinicians and researchers have been using ECS pharmacologyunknowinglyfor decades
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Factors such as body weight, metabolic rate, insulin sensitivity, gut microbiome composition, and genetic differences in receptor expression can all influence how effectively the medication suppresses appetite in any given person