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It's the hormone behind drugs like Ozempic, Zepbound and Retatrutide that have taken over almost every health headline for the past few years

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DKK, a WNT inhibitor, was a target gene of the NF-B pathway leading to a negative feedback to diminish the -catenin signaling 109

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The peptide consists of 39 amino acids engineered from a GIP peptide backbone, modified to stimulate all three target receptors

About this article Cite this article Graffeo, M.L., Dunleavy, J.E.M., Houston, B.J