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Additionally, topiroxostat inhibits the ATP-binding cassette transporter G2 (ABCG2), which plays a key role in renal uric acid reabsorption and the secretion of uric acid from the intestines

This hormone stimulates insulin, slows the movement of food through the stomach, and reduces the release of glucagon

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These mechanisms involve the gut flora, dysregulation of calcium signaling, mitochondrial dysfunction and oxidative stress, and pathological alterations in Tau proteins (Fesharaki-Zadeh and Datta, 2024)