(1) Adolescence (1218 years): high sensitivity to high-sugar diets Although human studies investigating the gut microbiome in adolescents remain limited, the ongoing development of the gut-brain axis and the adolescent brain suggests that this population may be particularly susceptible to diet-induced depressive symptoms (320), The impact of high-sugar diets on metabolic and intestinal health In male C57BL/6J mice, consumption of a high-glucose diet (HGD) over a 12-week period induces hyperglycemia, glucose intolerance, dyslipidemia, and increased adipose deposition
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Disruption in Neurotransmitter Receptor Remodeling Chronic ethanol consumption leads to significant disruptions in neurotransmitter receptor remodeling, a process that profoundly impacts mood regulation and contributes to the development of depression
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The alcohol concentration in serum showed a decrease in the GSH group compared to the placebo group, but the difference was not statistically significant, and the AUC and C max were not statistically different
