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Most patients with BMI 40 will likely choose retatrutide for its superior results, while those with BMI 30-40 may prefer CagriSema's faster availability

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In the cellular studies, NNC0090-2746 and tirzepatide showed comparable efficacy and potency at multiple signaling pathways connected to the GIPR

25 However, the specific contribution of the GIPR and GLP-1R to the pharmacological effects of dual incretin receptor agonism are currently undetermined