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This comprehensive mechanism addresses appetite, energy expenditure, gastric function, and glucose homeostasis through distinct but complementary receptor systems, potentially explaining enhanced efficacy observed in combination approaches compared to monotherapies

In vivo , B7-H3.CAR-T cells encoding either CD28 or 4-1BB equally controlled tumor growth and prolonged survival in 50% of treated mice as compared to controls

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CAR T cells targeting B7-H3, a pan-cancer antigen, demonstrate potent preclinical activity against pediatric solid tumors and brain tumors

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