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Additionally, the phenylalanine-rich region named crevasse in the inactive structure of the ghrelin receptor is absent in the motilin receptor ( 6.58 and Phe290 6.62 , located at the entrance of the ligand-binding pocket, are thought to contribute to the accessibility of the acyl-modified peptide through their hydrophobic properties ( Figure 4 Discussion Structural analyses of the ghrelin receptor, enabled by advancements in structural biology techniques such as X-ray crystallography and cryo-EM, have provided detailed insights into the molecular mechanisms underlying the recognition of active ghrelin by its receptor
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ClinicialTrials.gov (2023)