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2018 Salamun V et al

In pancreatic -cells, the primary role of GLP-1R is to promote -cell proliferation, stimulate insulin synthesis and secretion, and inhibit glucagon synthesis and release

This process enhances intracellular antioxidant expression and elevates the levels of intracellular antioxidant enzymes, thereby down-regulating oxidative stress (Yang et al., 2021

It promotes feelings of fullness, decreases hunger, and supports weight loss when combined with a healthy diet and exercise

Its derivation from -MSH connects it to the melanocortin system, which plays important roles in inflammation resolution and tissue homeostasis

Dosage Forms and Strengths Tablets: sitagliptin 100 mg and metformin HCl 1000 mg extended-release tablets are blue, bi-convex oval, film-coated tablets with 81 debossed on one side