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It has been discussed before, thatdue to the differential influence of enzymes and competing reactions in complex cellular systems 4,57 the midpoint redox potential of GRXs determined in vitro does not necessarily allow predictions on their redox states in vivo

Tumor size closely matched body weight and fat levels, suggesting fat reduction may slow cancer growth

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It could additionally be claimed that the relatively short-term duration of this study limits potential insights into the long-term sustainability of the weight loss observed and any treatment-associated adverse effects that may occur beyond the trial period