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GLP-1 directly activates POMC/CART neurons and indirectly inhibits, via GABAergic transmission, the neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, which collectively results in signals that reduce food intake

As of January 6, 2025 here is a list of approved and pending new GLP-1 agonists class of medications that can help manage Type 2 diabetes and obesity: Ozempic (semaglutide) Approved - A weekly injectable GLP-1 receptor agonist that helps regulate blood sugar and suppress appetite, promoting weight loss in addition to managing type 2 diabetes

To view or add a comment, sign in Struggling with GLP-1 therapy side effects

Liraglutide is approved in Europe for patients with T2DM and mild or moderate kidney damage, but is currently not recommended or should be used with caution in patients with severe renal impairment (130)

Some individuals may experience mild digestive sensitivity early on

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