Increased intracellular calcium inhibits enzymes responsible for the distribution of phospholipids in plasma membranes and the release of cytochrome C and apoptosis-inducing factors, triggering neuronal apoptotic death, suppressing neurotransmission, and cognitive dysfunction (Bezprozvanny and Mattson 2018)
Concomitant Treatments Significant differences were observed in concomitant antidiabetic therapies between groups (Table 1)
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The reporting of suspected adverse reactions that occur after the authorization of the drug is important, as it allows continuous monitoring of the benefit / risk ratio of the drug
We also believe the addition of the NPI data element will catalyze more fulsome HPT and Transparency in Coverage (TiC) analysis
One small study in nondiabetic patients noted a 6.5% weight loss with sitagliptin versus 7.65% with metformin, but larger trials in type 2 diabetes have not shown a direct effect on body weight