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Under the per-protocol approach, censoring events included discontinuation (no prescription of the index drug recorded within 90 days) and switching (prescription of the comparator drug)

For GSIS, islets were equilibrated for 1 h in KRB buffer (ESM Table 5) with 2.8 mmol/l glucose

It raises blood sugar by promoting glucose release from the liver and supports fat breakdown during fasting

Eli Lilly partnered with Fauna Bio to explore novel targets beyond GLP-1s, looking for ways to help humans maintain healthy metabolism during weight loss

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Methods Reagents Unless otherwise specified, all reagents were purchased from Sigma-Aldrich (St