Animal studies have shown that even chronic daily exposure did not significantly desensitize GH release mechanisms [5] , though cycling is recommended as a precautionary measure
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existing GI disorders
Mismanaged use can be extremely costly, damaging, and economically counterproductive, leading to lean mass loss, malnutrition, orthostatic events, injury, poor adherence, and rebound weight gain. Thats why organizations, including the Obesity Society and American Association of Clinical Endocrinology, continue to emphasize the importance of long-term care, not just for weight loss, but for weight maintenance and overall cardiometabolic health
Am J Physiol Cell Physiol 327(1):C205c12 Gardiner JV, Jayasena CN, Bloom SR (2008) Gut hormones: a weight off your mind
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