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88 found that the activated PPAR could induce the expression of its target gene uncoupling protein 2 (UCP2) and increase the activity of fatty acid -oxidation-related enzymes and peroxidase in mitochondria

The two mechanisms are independent and complementary

Ongoing research is focused on multi-target agonists, oral drugs, and broader therapeutic applications beyond diabetes and obesity, including cardiovascular, kidney, liver, and neurodegenerative conditions

pmid:24911948 2

The copies are manufactured using "solid state" peptide synthesis, and some have had contaminants like formaldehyde left inside