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Therapeutic response to cyanocobalamin may decrease due to elderly age, infection, renal insufficiency, diabetes mellitus, marrow suppressants use (e.g

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Astrocytic reactivity reflects activation of complex molecularly defined programmes which define remodelling of biochemical, morphological, metabolic, and physiological properties of astroglia leading to an upregulation or loss of homoeostatic cascades, or in gain of new protective or regenerative functions

For example, peptides are responsible for functions such as digestion, metabolism, weight loss, sexual desire, inflammation, neuropathy, and a myriad of age-related conditions

As many as 5000 local medicinal foods [189] directly sourced from the wild are used by traditional healers, who serve approximately 80% of the African population [190,191]