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The use and popularity of incretin mimetics have recently accelerated due to compelling data demonstrating an improvement in major clinical endpoints for patients with T2D and a reduction in cardiovascular events

When tirzepatide added GIP to GLP-1, it produced roughly 5-7 percentage points more weight loss than GLP-1 alone in the SURMOUNT-1 trial (Jepsen et al., NEJM 2022)

OGTT - oral glucose tolerance test

Based on the Human Protein Atlas (HPA) database, lower level of GPX4 and higher level of ACSL4 and ALOX15B (Fig