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These effects contribute to weight loss that varies by agent and dosetypically ranging from 5-8% with liraglutide 3 mg (Saxenda), up to 15% with semaglutide 2.4 mg (Wegovy), and potentially up to 20% with higher doses of tirzepatide (Zepbound)

She also outlined the value of patient-focused, non-judgmental baseline assessments prior to initiating GLP-1 RA therapy, as well as the benefits of considering the social determinants of health that affect an individual

Glucagon-like peptide-1 receptor agonists and risk of gastrointestinal cancers: a systematic review and meta-analysis of randomized controlled trials

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Ongoing research is focused on multi-target agonists, oral drugs, and broader therapeutic applications beyond diabetes and obesity, including cardiovascular, kidney, liver, and neurodegenerative conditions