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More unnecessary imaginary worlds part 4: the ICER evidence report for crizanlizumab, voxelotor and L-glutamine for sickle cell disease
10.1165/rcmb.2011-0380OC 29 DAmatoM.IadarolaP.ViglioS
Our DIA-MS proteomics analysis of early ring-stage parasites demonstrated that several proteins involved in the parasite respiratory chain, a known source of reactive oxygen species (ROS) 49 , are downregulated in parasites with PfK13 mutations, and since GSH scavenges ROS 23 , less ROS could contribute to the elevated GSH levels in these resistant parasites
Moreover, in order to further reduce burden, as discussed in more detail in prior sections of this final rule with comment period, we are delaying enforcement of our requirements to encode the new data elements in the MRF
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