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Clinically, its most often considered when progression is rapid, miniaturization is extensive, or finasteride hasnt provided adequate stabilization after a consistent trial

58 A realistic hypothesis is that this specific enzyme could behave similarly also in other mammalian species

Superoxide, Nitric Oxide and Peroxynitrite During normal respiration, a small percentage of electrons can escape the electron transport chain and reduce oxygen to superoxide

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However, under certain conditions, this deficiency may indicate some serious underlying health conditions, including cancers